睡眠(系统调用)
人类遗传学
生物
神经科学
遗传学
基因
计算机科学
操作系统
作者
Xianlin Zou,Louis J. Ptáček,Ying‐Hui Fu
出处
期刊:Annual Review of Genomics and Human Genetics
[Annual Reviews]
日期:2024-04-26
卷期号:25 (1): 259-285
被引量:2
标识
DOI:10.1146/annurev-genom-121222-120306
摘要
Healthy sleep is vital for humans to achieve optimal health and longevity. Poor sleep and sleep disorders are strongly associated with increased morbidity and mortality. However, the importance of good sleep continues to be underrecognized. Mechanisms regulating sleep and its functions in humans remain mostly unclear even after decades of dedicated research. Advancements in gene sequencing techniques and computational methodologies have paved the way for various genetic analysis approaches, which have provided some insights into human sleep genetics. This review summarizes our current knowledge of the genetic basis underlying human sleep traits and sleep disorders. We also highlight the use of animal models to validate genetic findings from human sleep studies and discuss potential molecular mechanisms and signaling pathways involved in the regulation of human sleep.
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