介观物理学
分区(防火)
纳米技术
计算机科学
领域(数学)
活性物质
认知科学
拓扑(电路)
数据科学
物理
生物
工程类
材料科学
数学
量子力学
核磁共振
纯数学
电气工程
酶
细胞生物学
心理学
作者
Debapriya Das,Ashok A. Deniz
出处
期刊:Biomolecules
[MDPI AG]
日期:2023-01-11
卷期号:13 (1): 151-151
被引量:4
摘要
Biomolecular condensation and phase separation are increasingly understood to play crucial roles in cellular compartmentalization and spatiotemporal regulation of cell machinery implicated in function and pathology. A key aspect of current research is to gain insight into the underlying physical mechanisms of these processes. Accordingly, concepts of soft matter and polymer physics, the thermodynamics of mixing, and material science have been utilized for understanding condensation mechanisms of multivalent macromolecules resulting in viscoelastic mesoscopic supramolecular assemblies. Here, we focus on two topological concepts that have recently been providing key mechanistic understanding in the field. First, we will discuss how percolation provides a network-topology-related framework that offers an interesting paradigm to understand the complex networking of dense ‘connected’ condensate structures and, therefore, their phase behavior. Second, we will discuss the idea of entanglement as another topological concept that has deep roots in polymer physics and important implications for biomolecular condensates. We will first review some historical developments and fundamentals of these concepts, then we will discuss current advancements and recent examples. Our discussion ends with a few open questions and the challenges to address them, hinting at unveiling fresh possibilities for the modification of existing knowledge as well as the development of new concepts relevant to condensate science.
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