金属
化学
水溶液中的金属离子
淀粉样蛋白(真菌学)
活性氧
氧化应激
肽
生物物理学
蛋白质聚集
氧化还原
离子
组合化学
生物化学
无机化学
生物
有机化学
作者
Seongmin Park,Chanju Na,J. Han,Mi Hee Lim
出处
期刊:Metallomics
[Oxford University Press]
日期:2023-01-01
卷期号:15 (1)
被引量:4
标识
DOI:10.1093/mtomcs/mfac102
摘要
The misfolding and aggregation of amyloid-β (Aβ) peptides are histopathological features found in the brains of Alzheimer's disease (AD). To discover effective therapeutics for AD, numerous efforts have been made to control the aggregation of Aβ species and their interactions with other pathological factors, including metal ions. Metal ions, such as Cu(II) and Zn(II), can bind to Aβ peptides forming metal-bound Aβ (metal-Aβ) complexes and, subsequently, alter their aggregation pathways. In particular, redox-active metal ions bound to Aβ species can produce reactive oxygen species leading to oxidative stress. In this review, we briefly illustrate some experimental approaches for characterizing the coordination and aggregation properties of metal-Aβ complexes.
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