化学免疫疗法
免疫原性
癌症免疫疗法
癌症研究
抗原性
免疫疗法
免疫系统
免疫检查点
癌症
体外
抗原
免疫学
生物
遗传学
生物化学
作者
Guiyuan Chen,Xiangxia Li,Rui Li,Kecheng Wu,Zhouhang Lei,Ruike Dai,Kyle C. Roche,Andrew Z. Wang,Yuanzeng Min
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-09-26
卷期号:17 (19): 18818-18831
被引量:3
标识
DOI:10.1021/acsnano.3c03274
摘要
Chemotherapeutics have the potential to increase the efficacy of cancer immunotherapies by stimulating the production of damage-associated molecular patterns (DAMPs) and eliciting mutations that result in the production of neoantigens, thereby increasing the immunogenicity of cancerous lesions. However, the dose-limiting toxicity and limited immunogenicity of chemotherapeutics are not sufficient to induce a robust antitumor response. We hypothesized that cancer cells in vitro treated with ultrahigh doses of various chemotherapeutics artificially increased the abundance, variety, and specificity of DAMPs and neoantigens, thereby improving chemoimmunotherapy. The in vitro chemotherapy-induced (IVCI) nanovaccines manufactured from cell lysates comprised multiple neoantigens and DAMPs, thereby exhibiting comprehensive antigenicity and adjuvanticity. Our IVCI nanovaccines exhibited enhanced immune responses in CT26 tumor-bearing mice, with a significant increase in CD4+/CD8+ T cells in tumors in combination with immune checkpoint inhibitors. The concept of IVCI nanovaccines provides an idea for manufacturing and artificial enhancement of immunogenicity vaccines to improve chemoimmunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI