Et tu neutrophils? The brain reprograms neutrophils to facilitate tumor progression

Neutrophils have remained understudied in malignant brain tumors. In a recent issue of Cell, Maas et al. analyze brain tumor-patient samples and demonstrate that the brain microenvironment reprograms infiltrating neutrophils to enhance their longevity and increase their immune-suppressive and pro-angiogenic properties. Neutrophils have remained understudied in malignant brain tumors. In a recent issue of Cell, Maas et al. analyze brain tumor-patient samples and demonstrate that the brain microenvironment reprograms infiltrating neutrophils to enhance their longevity and increase their immune-suppressive and pro-angiogenic properties. The local microenvironment drives activation of neutrophils in human brain tumorsMaas et al.CellSeptember 27, 2023In BriefComprehensive analyses of brain tumor-associated neutrophils in humans and mice reveal a multifaceted pro-tumoral phenotype, which is induced by soluble factors secreted by tumor-associated myeloid cells. Full-Text PDF Open Access