Brain–computer interface relieves chronic chemotherapy‐induced peripheral neuropathy: A randomized, double‐blind, placebo‐controlled trial

医学 脑-机接口 安慰剂 置信区间 随机对照试验 随机化 周围神经病变 化疗所致周围神经病变 脑电图 内科学 精神科 替代医学 病理 糖尿病 内分泌学
作者
Sarah Prinsloo,Ted J. Kaptchuk,Dirk De Ridder,Randall R. Lyle,Éduardo Bruera,Diane M. Novy,Carlos H. Bárcenas,Lorenzo Cohen
出处
期刊:Cancer [Wiley]
卷期号:130 (2): 300-311 被引量:4
标识
DOI:10.1002/cncr.35027
摘要

Abstract Background Chemotherapy‐induced peripheral neuropathy (CIPN) includes negative sensations that remain a major chronic problem for cancer survivors. Previous research demonstrated that neurofeedback (a closed‐loop brain–computer interface [BCI]) was effective at treating CIPN versus a waitlist control (WLC). The authors' a priori hypothesis was that BCI would be superior to placebo feedback (placebo control [PLC]) and to WLC in alleviating CIPN and that changes in brain activity would predict symptom report. Methods Randomization to one of three conditions occurred between November 2014 and November 2018. Breast cancer survivors no longer in treatment were assessed at baseline, at the end of 20 treatment sessions, and 1 month later. Auditory and visual rewards were given over 20 sessions based on each patient's ability to modify their own electroencephalographic signals. The Pain Quality Assessment Scale (PQAS) at the end of treatment was the primary outcome, and changes in electroencephalographic signals and 1‐month data also were examined. Results The BCI and PLC groups reported significant symptom reduction. The BCI group demonstrated larger effect size differences from the WLC group than the PLC group (mean change score: BCI vs. WLC, −2.60 vs. 0.38; 95% confidence interval, −3.67, −1.46 [ p = .000; effect size, 1.07]; PLC, −2.26; 95% confidence interval, −3.33, −1.19 [ p = .001 vs. WLC; effect size, 0.9]). At 1 month, symptoms continued to improve only for the BCI group. Targeted brain changes at the end of treatment predicted symptoms at 1 month for the BCI group only. Conclusions BCI is a promising treatment for CIPN and may have a longer lasting effect than placebo (nonspecific BCI), which is an important consideration for long‐term symptom relief. Although scientifically interesting, the ability to separate real from placebo treatment may not be as important as understanding the placebo effects differently from effects of the intervention. Plain Language Summary Chemotherapy‐induced nerve pain (neuropathy) can be disabling for cancer survivors; however, the way symptoms are felt depends on how the brain interprets the signals from nerves in the body. We determined that the perception of neuropathy can be changed by working directly with the brain. Survivors in our trial played 20 sessions of a type of video game that was designed to change the way the brain processed sensation and movement. In this, our second trial, we again observed significant improvement in symptoms that lasted after the treatment was complete.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
打打应助科研通管家采纳,获得10
1秒前
传奇3应助科研通管家采纳,获得10
1秒前
思源应助科研通管家采纳,获得10
1秒前
1秒前
大个应助科研通管家采纳,获得10
1秒前
Ava应助科研通管家采纳,获得10
1秒前
香蕉觅云应助科研通管家采纳,获得10
1秒前
Ava应助科研通管家采纳,获得10
1秒前
1秒前
byron完成签到,获得积分10
3秒前
sauyu完成签到 ,获得积分10
3秒前
ccq发布了新的文献求助10
3秒前
难摧发布了新的文献求助10
4秒前
orixero应助wangayting采纳,获得30
5秒前
猪猪完成签到,获得积分10
5秒前
shubido完成签到,获得积分10
7秒前
白日梦小说家完成签到 ,获得积分10
8秒前
懒羊羊完成签到 ,获得积分10
8秒前
猪猪发布了新的文献求助10
8秒前
Pauline完成签到 ,获得积分10
10秒前
11秒前
fugdu完成签到,获得积分10
12秒前
受伤书文完成签到,获得积分10
12秒前
13秒前
遠山完成签到,获得积分10
15秒前
16秒前
17秒前
lhs发布了新的文献求助10
17秒前
脑洞疼应助坚强的纸鹤采纳,获得10
20秒前
joyboysimba发布了新的文献求助10
22秒前
24秒前
暖羊羊Y完成签到 ,获得积分10
24秒前
24秒前
24秒前
英俊的筝发布了新的文献求助10
26秒前
可爱的函函应助木木木木采纳,获得10
27秒前
佳音发布了新的文献求助30
28秒前
英姑应助难摧采纳,获得10
29秒前
29秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137539
求助须知:如何正确求助?哪些是违规求助? 2788516
关于积分的说明 7787054
捐赠科研通 2444818
什么是DOI,文献DOI怎么找? 1300043
科研通“疑难数据库(出版商)”最低求助积分说明 625784
版权声明 601023