医学
肿瘤科
内科学
危险系数
化疗
癌症
总体生存率
置信区间
作者
Louise Faaborg,Rikke Fredslund Andersen,Sara Witting Christensen Wen,Caroline Brenner Thomsen,Louise Raunkilde,Torben Frøstrup Hansen,Lars Henrik Jensen,Karina Dahl Steffensen,Anders Jakobsen
出处
期刊:Future Oncology
[Future Medicine]
日期:2023-11-01
卷期号:19 (35): 2361-2367
标识
DOI:10.2217/fon-2023-0111
摘要
Aim: Clinical utility of the dynamics of ctDNA is sparse. This study aimed at evaluating the prognostic impact of early ctDNA dynamics in patients with metastatic cancer treated with chemotherapy. Materials & methods: The ctDNA dynamics were evaluated in 595 patients with metastatic cancer using droplet digital PCR. Results: Patients with an increase in ctDNA after one treatment cycle (n = 73; 12.2%) had an overall survival of 5.6 months compared with 8.6 months in patients with stable or decreasing ctDNA (n = 328; 55.1%) and 21.0 months in patients with undetectable ctDNA (p < 0.001; hazard ratio: 0.47; 95% CI: 0.41-0.53). Conclusion: Early ctDNA dynamics hold important prognostic information and have great implications for evaluation with the perspective of a more individualized treatment strategy.
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