Cardiac radiation dose is associated with inferior survival but not cardiac events in patients with locally advanced non-small cell lung cancer in the era of immune checkpoint inhibitor consolidation

医学 内科学 心脏病学 狼牙棒 累积发病率 临床终点 心力衰竭 肺癌 冠状动脉疾病 心肌梗塞 移植 经皮冠状动脉介入治疗 随机对照试验
作者
Nikhil Yegya‐Raman,Sang Ho Lee,Cole Friedes,Xingmei Wang,Michelle Iocolano,Timothy P. Kegelman,Lian Duan,Bolin Li,Eva Berlin,Kristine Kim,Abigail Doucette,Srinivas Denduluri,William P. Levin,Keith A. Cengel,Roger B. Cohen,Corey J. Langer,Boon‐Keng Teo,Wei Zou,Rupal P. O'Quinn,Joseph O. Deasy,Jeffrey D. Bradley,Lova Sun,Bonnie Ky,Ying Xiao,Steven J. Feigenberg
出处
期刊:Radiotherapy and Oncology [Elsevier]
卷期号:190: 110005-110005 被引量:6
标识
DOI:10.1016/j.radonc.2023.110005
摘要

Abstract

Purpose

We assessed the association of cardiac radiation dose with cardiac events and survival post-chemoradiation therapy (CRT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) after adoption of modern radiation therapy (RT) techniques, stricter cardiac dose constraints, and immune checkpoint inhibitor (ICI) consolidation.

Methods and Materials

This single-institution, multi-site retrospective study included 335 patients with LA-NSCLC treated with definitive, concurrent CRT between October 2017 and December 2021. All patients were evaluated for ICI consolidation. Planning dose constraints included heart mean dose < 20 Gy (<10 Gy if feasible) and heart volume receiving ≥ 50 Gy (V50Gy) < 25 %. Twenty-one dosimetric parameters for three different cardiac structures (heart, left anterior descending coronary artery [LAD], and left ventricle) were extracted. Primary endpoint was any major adverse cardiac event (MACE) post-CRT, defined as acute coronary syndrome, heart failure, coronary revascularization, or cardiac-related death. Secondary endpoints were: grade ≥ 3 cardiac events (per CTCAE v5.0), overall survival (OS), lung cancer-specific mortality (LCSM), and other-cause mortality (OCM).

Results

Median age was 68 years, 139 (41 %) had baseline coronary heart disease, and 225 (67 %) received ICI consolidation. Proton therapy was used in 117 (35 %) and intensity-modulated RT in 199 (59 %). Median LAD V15Gy was 1.4 % (IQR 0–22) and median heart mean dose was 8.7 Gy (IQR 4.6–14.4). Median follow-up was 3.3 years. Two-year cumulative incidence of MACE was 9.5 % for all patients and 14.3 % for those with baseline coronary heart disease. Two-year cumulative incidence of grade ≥ 3 cardiac events was 20.4 %. No cardiac dosimetric parameter was associated with an increased risk of MACE or grade ≥ 3 cardiac events. On multivariable analysis, cardiac dose (LAD V15Gy and heart mean dose) was associated with worse OS, driven by an association with LCSM but not OCM.

Conclusions

With modern RT techniques, stricter cardiac dose constraints, and ICI consolidation, cardiac dose was associated with LCSM but not OCM or cardiac events in patients with LA-NSCLC.
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