医学
生物标志物
内科学
神经血管束
人口统计学的
创伤性脑损伤
胃肠病学
病理
生物
精神科
生物化学
人口学
社会学
作者
Huimin Zhu,Xiaodong Jia,Zheng-Kang Fang,Chengyi Zhang,Ningning Wang,Haoxiao Chang,Fu‐Dong Shi,Fu‐Dong Shi,Wenyan He
出处
期刊:Clinical Laboratory
[Clinical Laboratory Publications]
日期:2023-01-01
卷期号:69 (11/2023)
标识
DOI:10.7754/clin.lab.2023.230215
摘要
Brain injury triggers neuroaxonal injury and neural death, that leads to the development of secondary sequelae. Throughout this process, brain injury factors released into circulation via the injured neurovascular unit are important prognostic parameters. Plasma NfL, NfH, MCP-1, and MMP-9 have been identified as potential indicators in this regard.Using a microfluidic ELISA platform, we measured plasma from 273 healthy subjects that underwent quantifications of NfL, NfH, MCP-1, and MMP-9 levels. We investigated the possible associations between biomarkers and basic demographics.The median concentration of plasma NfL was 10.40 (IQR = 6.73 - 16.60) pg/mL, NfH was 70.70 (IQR = 39.75 - 125.50) pg/mL, MCP-1 was 191.0 (IQR = 162.0 - 237.5) pg/mL, and MMP-9 was 169,255 (IQR = 107,657 - 231,276) pg/mL. Among all four biomarkers, plasma NfL and NfH levels were positively correlated with age (r = 0.557, p < 0.001, r = 0.364, p = 0.003). NfL was also correlated with NfH (r = 0.391, p = 0.002).These data provide a basis for the potential application of a brain-injury biomarker panel in routine clinical practice. It lays a significant foundation in supporting circulating CNS-biomarkers as noninvasive biomarkers for neurological disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI