The development of disposable electrochemical sensor based on MoSe2-rGO nanocomposite modified screen printed carbon electrode for amitriptyline determination in the presence of carbamazepine, application in biological and water samples

The present attempt developed a simple sensing system based on the modification of screen-printed carbon electrode (SPCE) with MoSe2/reduced graphene oxide (rGO) nanocomposite (MoSe2-rGO/SPCE) to voltammetrically co-detect amitriptyline and carbamazepine. Different techniques such as field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) were employed to characterize MoSe2-rGO nanocomposite morphology and structure. Moreover, chronoamperometry, differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) were utilized to explore the electrochemical oxidation of amitriptyline. Data revealed a great current sensitivity for the MoSe2-rGO/SPCE towards amitriptyline. The peak currents of amitriptyline oxidation on the MoSe2-rGO/SPCE had linear dynamic range (0.02-380.0 μM) and a narrow limit of detection (0.007 μM). The MoSe2-rGO/SPCE was successful in sensing carbamazepine and amitriptyline in real specimens, with appreciable recovery rates.