AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated glycolysis

In conclusion, AST-120 alleviates renal IRI via suppressing HK2-mediated glycolysis, which suppresses H3K18 lactylation and further reduces HK2 levels. This study proposes a novel mechanism by which AST-120 alleviates IRI.