[Research progresses on interventions of obesity in children and adolescents].

Childhood and adolescent obesity has become a global epidemic. The interventions mainly include lifestyle intervention, medication treatment and bariatric surgery. Among them, lifestyle intervention, especially intensive lifestyle intervention with participation of family members, is the first-line treatment for obesity in children and adolescents. Both medication and bariatric surgery are adjuvant treatments for severely obese children and adolescents. Currently, metformin is the most widely used drug for the treatment of obesity in children and adolescents in both China and other countries; orlistat and liraglutide are also the drugs that are safe and often used in other countries; other drugs are not recommended. As a tertiary prevention and treatment strategy for obesity, bariatric surgery should be carried out on the basis of good compliance from both the children and their family members, with the cooperation of multiple disciplines. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most common types of procedure performed. Meanwhile, as a new treatment method, intra-gastric balloon procedure needs to be paid more attention to its efficacy and safety.儿童青少年肥胖已经成为一种全球流行病，干预手段主要包括生活方式干预、药物治疗和手术治疗三个方面。其中生活方式干预，尤其是家庭参与的强化生活方式干预是儿童青少年肥胖的一线治疗方法。药物治疗和外科手术是严重肥胖儿童青少年的辅助治疗手段。目前治疗儿童青少年肥胖国内外临床应用最多的药物为二甲双胍，国外应用较多且安全性较高的药物还有奥利司他、利拉鲁肽，其他药物均不推荐。手术治疗作为肥胖的三级预防治疗措施，应在患儿及其家属具有良好的依从性，多学科合作共同配合下进行，常用的术式为袖状胃切除术（SG），Roux-en-Y胃旁路术（RYGB）；球囊内镜作为新兴的治疗方式有待进一步关注其疗效及安全性。.