止血
材料科学
海绵
明胶海绵
明胶
锥面
生物医学工程
多孔性
微通道
止血剂
纳米技术
穿孔
复合材料
化学
外科
医学
栓塞
生物化学
植物
冲孔
生物
作者
Lina Cao,Zhixiao Ji,Bingxu Zhang,Xiaoqin Si,Yuzhen Wang,Jiahui Hao,Xujian Li,Wei-Hua Mu,Xiao Yang,Changcan Shi
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2023-03-17
卷期号:9 (4): 2001-2013
被引量:1
标识
DOI:10.1021/acsbiomaterials.3c00161
摘要
It remains a challenge to develop effective hemostatic products in battlefield rescue for noncompressible massive hemorrhage. Some previous research had concentrated on the modification of different materials to improve the hemostasis ability of sponges. Herein, to investigate the relationship between the taper of microchannels and hemostatic performance of porous sponges, gelatin methacryloyl-based sponges with designed conical microchannels and a disordered porous structure were prepared using the 3D printing method and freeze-drying technology. Experiments and theoretical model analysis demonstrated that the taper and distribution of microchannels in the sponge affected the water and blood absorption properties, as well as the expansion ability. In treatment of SD rat liver defect and SD rat liver perforation wound, GS-1 sponge with the taper (1/15) microchannels exhibited an excellent hemostatic effect with blood loss of 0.866 ± 0.093 g and a hemostasis time of 280 ± 10 s. Results showed that the hemostatic capacities of GelMA sponges were increased with the bottom diameter (taper) of conical microchannels. This is a potential strategy to develop designed taper sponges with designed taper microchannels for rapidly controlling hemorrhage.
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