WCN23-0066 Identifying druggable pathways in IgA Nephropathy using spatial transcriptomics

IgA nephropathy (IgAN) is the most commonly reported primary glomerular disease worldwide. It mainly affects young adults; about 30% develop kidney failure 10-20 years from diagnosis. Five histopathological kidney lesions independently predict a poor prognosis in IgAN (MEST-C score). Published case series highlight the 'endocapillary hypercellularity' (E1) lesion as potentially reversible with systemic immunosuppression, improving clinical outcomes. E1 is defined by the obliteration of glomerular capillary lumens by cells that appear to be mostly macrophages.