A novel dopamine electrochemical sensor based on 3D flake nickel oxide/ cobalt oxide @ porous carbon nanosheets/carbon nanotubes/electrochemical reduced of graphene oxide composites modified glassy carbon electrode

Dopamine (DA), as an typical neurotransmitter, was believed to play important roles in addiction and some neurodegenerative diseases. Accurately and rapidly detection of DA is very valuable. In this study, a sensor based on 3D flake nickel oxide/ cobalt [email protected] carbon nanosheets/carbon nanotubes/ electrochemical reduced of graphene oxide composites modified glassy carbon electrode (NiO/[email protected]/CNTs/erGO/GCE) was constructed. The flake NiO/[email protected]/CNTs were obtained by directly pyrolysis Ni/Co-MOF under nitrogen protection, which presented excellent electrochemical properties due to the synergistic catalytic effect and porous sheet structure. For the detection of DA, the NiO/[email protected]/CNTs/erGO/GCE showed wider linear range (0.10 μM – 22.0 μM) and the detection limit (LOD) of DA was 0.045 μM, (S/N = 3). Additionally, the reaction sites and mechanism of DA were revealed by analyzing the electrochemical behavior with the help of density functional calculation. Moreover, the sensor showed satisfactory results in the determination of DA in real biological sample.