斯达
JAK-STAT信号通路
生物
效应器
信号转导
背景(考古学)
细胞生物学
车站3
免疫
免疫系统
神经科学
免疫学
酪氨酸激酶
古生物学
作者
Alejandro V. Villarino,Yuka Kanno,John R. Ferdinand,John J. O’Shea
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2014-12-19
卷期号:194 (1): 21-27
被引量:462
标识
DOI:10.4049/jimmunol.1401867
摘要
Abstract More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membrane-to-nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene expression, it also has become a prototype for transition from bench to bedside, culminating in the development and clinical implementation of pathway-specific therapeutics. This brief review synthesizes our current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.
科研通智能强力驱动
Strongly Powered by AbleSci AI