Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway

• DZSM improves cognition by facilitating LTP. • DZSM regulates the NMDA receptor-mediated Ca 2+ /CaMKII pathway. • Flavonoids and caffeoyl compounds are active components of DZSM. • Scutellarin is promising to treat cognitive deficits.