微生物群
肠道微生物群
肠道菌群
肠道细菌
计算生物学
药品
生物技术
生物
医学
风险分析(工程)
生化工程
药理学
生物信息学
免疫学
工程类
作者
Xiaoxiang Gao,Wei Chen,Wei Chen,Qixiao Zhai
标识
DOI:10.1016/j.phrs.2023.106867
摘要
Most diets and medications enhance host health via microbiota-dependent ways, but it is in the present situation of untargeted regulation. Non-targeted regulation may lead to the ineffectiveness of dietary supplements or drug treatment. Microbiota-directed food, aiming to improve diseases by targeting specific microbes without affecting other bacteria, have been proposed to deal with this problem. However, there is currently no universally applicable method to explore such foods or drugs. In this review, thirty studies on recent efforts in microbiota directed diets and medications are summarized from various databases. The methods used to find new foods and medications are primarily divided into four groups depending on the experimental models: in vivo and in vitro, as well as predictions based on bioinformatics. We also discuss their implementation, interpretation, and respective limitations, and describe the present situation. We further put forward a framework for microbiota-directed foods and medicine according to above methods and other microbiome manipulation, which will spur precision medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI