生物
癌变
遗传学
体细胞
等位基因
基因型
基因
癌症
作者
Teng Gao,Maria Eleni Kastriti,Viktor Ljungström,Andreas Heinzel,Arthur S. Tischler,Rainer Oberbauer,Po‐Ru Loh,Igor Adameyko,Peter J. Park,Peter V. Kharchenko
出处
期刊:Nature Genetics
[Springer Nature]
日期:2023-10-30
卷期号:55 (11): 1901-1911
被引量:4
标识
DOI:10.1038/s41588-023-01537-1
摘要
Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic single-nucleotide variants have been well characterized in the human body, the patterns and consequences of large chromosomal alterations in normal tissues remain largely unknown. Here, we present a pan-tissue survey of mosaic chromosomal alterations (mCAs) in 948 healthy individuals from the Genotype-Tissue Expression project, augmenting RNA-based allelic imbalance estimation with haplotype phasing. We found that approximately a quarter of the individuals carry a clonally-expanded mCA in at least one tissue, with incidence strongly correlated with age. The prevalence and genome-wide patterns of mCAs vary considerably across tissue types, suggesting tissue-specific mutagenic exposure and selection pressures. The mCA landscapes in normal adrenal and pituitary glands resemble those in tumors arising from these tissues, whereas the same is not true for the esophagus and skin. Together, our findings show a widespread age-dependent emergence of mCAs across normal human tissues with intricate connections to tumorigenesis. Analysis of GTEx RNA-seq samples identifies hundreds of mosaic chromosomal alterations (mCAs). Considerable inter-tissue variability and excess incidence of mCAs across malignancies suggest a complex relationship with tumorigenesis.
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