Ins and Outs of Glutathione in Cardiac Ischemia/Reperfusion Injury

HomeCirculation ResearchVol. 133, No. 10Ins and Outs of Glutathione in Cardiac Ischemia/Reperfusion Injury No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextIns and Outs of Glutathione in Cardiac Ischemia/Reperfusion Injury Edoardo Bertero and Christoph Maack Edoardo BerteroEdoardo Bertero Correspondence to: Edoardo Bertero, MD, PhD, Department of Internal Medicine, University of Genova, Genova, Italy. Email: E-mail Address: [email protected] Department of Internal Medicine, University of Genova, Italy (E.B.). Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino – Italian IRCCS Cardiology Network, Genova (E.B.). Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Germany (E.B., C.M.). and Christoph MaackChristoph Maack https://orcid.org/0000-0003-3694-4559 Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Germany (E.B., C.M.). Originally published26 Oct 2023https://doi.org/10.1161/CIRCRESAHA.123.323715Circulation Research. 2023;133:877–879This article is a commentary on the followingMRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-ReperfusionFootnotesFor Sources of Funding and Disclosures, see page 878 & 879.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Edoardo Bertero, MD, PhD, Department of Internal Medicine, University of Genova, Genova, Italy. Email: edo.bertero@gmail.comReferences1. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. 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MRP1-dependent extracellular release of glutathione induces cardiomyocyte ferroptosis after ischemia-reperfusion.Circulation Research. 2022; 133:861–876. doi: 10.1161/CIRCRESAHA.123.323517LinkGoogle Scholar9. Chouchani ET, Pell VR, Gaude E, Aksentijevic D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Nature. 2014; 515:431–435. doi: 10.1038/nature13909CrossrefMedlineGoogle Scholar10. Prag HA, Aksentijevic D, Dannhorn A, Giles AV, Mulvey JF, Sauchanka O, Du L, Bates G, Reinhold J, Kula-Alwar D, et al. Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury.Circ Res. 2022; 131:528–541. doi: 10.1161/CIRCRESAHA.121.320717LinkGoogle Scholar11. Fang X, Ardehali H, Min J, Wang F. 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Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-ReperfusionGenki Ichihara, et al. Circulation Research. 2023;133:861-876 October 27, 2023Vol 133, Issue 10 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.323715PMID: 37883592 Originally publishedOctober 26, 2023 KeywordsEditorialsferroptosisglutathioneischemiareperfusionPDF download Advertisement