Triazole hybrid compounds: A new frontier in malaria treatment

疟疾 药效团 恶性疟原虫 计算生物学 药理学 药品 部分 化学 生物技术 组合化学 生物 立体化学 免疫学
作者
Lekkala Ravindar,Siti Aishah Hasbullah,K.P. Rakesh,Nurul Izzaty Hassan
出处
期刊:European journal of medicinal chemistry [Elsevier]
卷期号:259: 115694-115694 被引量:28
标识
DOI:10.1016/j.ejmech.2023.115694
摘要

Reviewing the advancements in malaria treatment, the emergence of triazole hybrid compounds stands out as a groundbreaking development. Combining the advantages of triazole and other moieties, these hybrid compounds offer a new frontier in the battle against malaria. Their potential as effective antimalarial agents has captured the attention of researchers and holds promise for overcoming the challenges posed by drug-resistant malaria strains. We focused on their broad spectrum of antimalarial activity of diverse hybridized 1,2,3-triazoles and 1,2,4-triazoles, structure-activity relationship (SAR), drug-likeness, bioavailability and pharmacokinetic properties reported since 2018 targeting multiple stages of the Plasmodium life cycle. This versatility makes them highly effective against both drug-sensitive and drug-resistant strains of P. falciparum, making them invaluable tools in regions where resistance is prevalent. The synergistic effects of combining the triazole moiety with other pharmacophores have resulted in even greater antimalarial potency. This approach has the potential to circumvent existing resistance mechanisms and provide a more sustainable solution to malaria treatment. While triazole hybrid compounds show great promise, further research and clinical trials are warranted to fully evaluate their safety, efficacy and long-term effects. As research progresses, these compounds can potentially revolutionize the field and contribute to global efforts to eradicate malaria, ultimately saving countless lives worldwide.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lucas应助BZPL采纳,获得10
刚刚
轻松的桐发布了新的文献求助20
刚刚
开心的元冬完成签到,获得积分20
刚刚
大气青枫完成签到,获得积分10
1秒前
1秒前
2秒前
Eman完成签到,获得积分10
2秒前
36456657应助plsdntc采纳,获得10
2秒前
lizi发布了新的文献求助10
2秒前
小慕斯应助微笑傲南采纳,获得10
2秒前
ash发布了新的文献求助10
2秒前
栗子完成签到 ,获得积分10
2秒前
3秒前
狂吃五碗饭完成签到,获得积分10
3秒前
jaysecret完成签到,获得积分10
3秒前
西门吹雪9527完成签到,获得积分10
3秒前
CC完成签到,获得积分10
3秒前
3秒前
爱笑宛亦完成签到,获得积分10
3秒前
4秒前
jinkk完成签到,获得积分10
4秒前
丘比特应助SUKAILIMAI采纳,获得10
5秒前
zyh945发布了新的文献求助10
5秒前
5秒前
柚子完成签到,获得积分10
5秒前
123完成签到,获得积分10
5秒前
fireflieszy完成签到,获得积分10
5秒前
高贵梦秋发布了新的文献求助10
5秒前
amateur完成签到,获得积分10
5秒前
小酒迟疑完成签到,获得积分10
6秒前
sll完成签到,获得积分10
6秒前
坚强亦丝应助科研通管家采纳,获得10
6秒前
6秒前
小蘑菇应助科研通管家采纳,获得10
6秒前
菠菜应助科研通管家采纳,获得100
6秒前
桐桐应助nwds采纳,获得10
6秒前
CipherSage应助科研通管家采纳,获得10
6秒前
6秒前
prosperp应助科研通管家采纳,获得10
6秒前
Hello应助科研通管家采纳,获得10
6秒前
高分求助中
Continuum thermodynamics and material modelling 3000
Production Logging: Theoretical and Interpretive Elements 2500
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 2000
Applications of Emerging Nanomaterials and Nanotechnology 1111
Covalent Organic Frameworks 1000
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Theory of Block Polymer Self-Assembly 750
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3477918
求助须知:如何正确求助?哪些是违规求助? 3069237
关于积分的说明 9112402
捐赠科研通 2760784
什么是DOI,文献DOI怎么找? 1515087
邀请新用户注册赠送积分活动 700570
科研通“疑难数据库(出版商)”最低求助积分说明 699712