A comparative study of esketamine-dexmedetomidine and sufentanil-dexmedetomidine for sedation and analgesia in lung tumor percutaneous radiofrequency ablation (PRFA): a randomized double-blind clinical trial

右美托咪定 医学 麻醉 舒芬太尼 镇静 氯胺酮 围手术期 可视模拟标度
作者
Zhonglan Lin,Shuxin Li,Yun Zhou,Xiuyuan Lu,Bin Yang,Zusheng Yu,Yuan Cheng,Jianliang Sun
出处
期刊:BMC Anesthesiology [BioMed Central]
卷期号:23 (1) 被引量:4
标识
DOI:10.1186/s12871-023-02266-y
摘要

Abstract Objective To observe and evaluate the effectiveness and safety of Esketamine or Sufentanil combined with Dexmedetomidine for sedation and analgesia in lung tumor percutaneous radiofrequency ablation (PRFA) to provide a clinical basis for the optimization of sedation and analgesia in lung tumor PRFA protocols outside the operating room. Methods In this trial, 44 patients aged 37 to 84 undergoing lung tumor PRFA were enrolled and assigned to Group E (n = 22, Esketamine 0.2 mg/kg) or Group S (n = 22,Sufentanil 0.1 μg/kg ). Dexmedetomidine was infused intravenously as a sedative in both groups. The modified observer’s assessment of alertness and sedation scale (MOAAS), physical movement pain scale, intraoperative vital signs, anesthesia recovery time, radiologist and patient satisfaction rates, incidence of respiratory depression, and incidence of postoperative nausea and vomiting were recorded. Results Although there was no significant difference in the physical movement pain scale, blood oxygen saturation or incidence of perioperative adverse events between the two groups during ablation, the MOAAS, mean arterial pressure (MAP) and heart rate (HR) were higher in Group E than in Group S. The anesthesia recovery time was shorter in Group E than in Group S, and radiologist satisfaction was better in Group E than in Group S, but there was no significant difference between the two groups in terms of patient satisfaction. Conclusion Esketamine or Sufentanil combined with Dexmedetomidine is safe for lung tumor PRFA. However, in elderly patients with multiple underlying diseases, low-dose Esketamine combined with Dexmedetomidine has fewer hemodynamic effects on patients, milder respiratory depression, shorter recovery time, and better radiologist satisfaction because of its better controllability of sedation depth. Trial registration Chinese Clinical Trial Registry (Registration number#ChiCTR ChiCTR21000500 21); Date of Registration: 16/08/2021
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
小东西725完成签到,获得积分20
刚刚
研友_LOKXmL完成签到,获得积分10
1秒前
哈哈发布了新的文献求助20
1秒前
谈舒怡发布了新的文献求助10
2秒前
春晓发布了新的文献求助10
3秒前
5秒前
5秒前
端庄毛巾发布了新的文献求助30
5秒前
大模型应助MrRen采纳,获得10
7秒前
yukaiyuan发布了新的文献求助10
7秒前
polite完成签到 ,获得积分10
9秒前
毕蓝血完成签到 ,获得积分10
9秒前
lululala发布了新的文献求助10
10秒前
甜美的成败完成签到,获得积分10
10秒前
11秒前
研友_VZG7GZ应助我门牙有缝采纳,获得10
11秒前
11秒前
yalin完成签到,获得积分10
12秒前
15秒前
能干耳机发布了新的文献求助10
15秒前
16秒前
18秒前
18秒前
20秒前
bkagyin应助dd采纳,获得10
20秒前
SciGPT应助Seoyeong采纳,获得10
20秒前
wxy发布了新的文献求助10
21秒前
22秒前
imxiaobing发布了新的文献求助10
22秒前
XiaoMing完成签到,获得积分10
22秒前
Muhammad发布了新的文献求助10
23秒前
23秒前
24秒前
你看起来很好吃完成签到,获得积分10
24秒前
25秒前
26秒前
zyn完成签到,获得积分10
27秒前
嗯呐发布了新的文献求助10
27秒前
Chengcheng发布了新的文献求助30
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976126
求助须知:如何正确求助?哪些是违规求助? 3520340
关于积分的说明 11202586
捐赠科研通 3256847
什么是DOI,文献DOI怎么找? 1798509
邀请新用户注册赠送积分活动 877645
科研通“疑难数据库(出版商)”最低求助积分说明 806516