A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients

列线图 医学 肝内胆管癌 癌胚抗原 内科学 肝硬化 多元分析 胃肠病学 肿瘤科 生存分析 癌症
作者
Yinghao Lv,Hu Liu,Penghui He,Sinan Xie,Xiuchun Yin,Yunshi Cai,Hong Wu
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:13 (1) 被引量:4
标识
DOI:10.1038/s41598-023-45056-9
摘要

Intrahepatic cholangiocarcinoma (ICC) accounts for 20% of liver malignancies with a 5-year survival rate of 35% at best with limited prognostic predictors. Lung Immune Prognostic Index (LIPI) is a novel prognostic factor in pulmonary cancers. In this study, we developed a modified prognostic model from LIPI called intrahepatic immune prognostic index (IIPI) for ICC. A retrospectively study was conducted at Liver Transplant Center of West China Hospital between January 2015 and January 2023. Hematological factors and clinical features of ICC patients were collected and analyzed. The area under curve (AUC) and optimal cuff-off of each single hematological factor was calculated. In this study, derived neurtrophil to lymphocyte ratio (dNLR), arbohydrate antigen199 (CA199) and carcinoembryonic antigen (CEA) have higher AUC values. LIPI was composed of dNLR and was further modified by combing CA199 and CEA, forming the IIPI. The IIPI consists of four grades which are None, Light, Moderate and Severe. Compared to other prognostic factors, IIPI exhibited better ability to predict overall survival. The multivariate analysis indicated that cirrhosis, differentiation, hilar invasion and IIPI were independent prognostic factors for ICC patients. An IIPI-based nomogram was also established and could predict the overall survival. In addition, the subgroup analyses based on clinical prognostic factors showed that the IIPI exhibited excellent prognostic influence. IIPI model is suitable for predicting the prognosis of postoperative ICC patients. Further research is needed to explore the relationship between postoperative recurrence and metastasis of ICC patients and IIPI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SciGPT应助seventeen采纳,获得10
刚刚
刚刚
复杂的板凳完成签到,获得积分10
1秒前
1秒前
1秒前
蓝桉完成签到,获得积分10
2秒前
Yun发布了新的文献求助10
2秒前
3秒前
王彦红发布了新的文献求助10
4秒前
4秒前
大个应助失眠的莫英采纳,获得10
4秒前
孤独士晋发布了新的文献求助10
4秒前
沧海发布了新的文献求助10
5秒前
阿双发布了新的文献求助30
5秒前
5秒前
NexusExplorer应助激战小唐僧采纳,获得10
5秒前
博士发布了新的文献求助10
6秒前
危机的酒窝完成签到,获得积分10
7秒前
7秒前
雅丽发布了新的文献求助10
7秒前
十一发布了新的文献求助10
8秒前
研友_V8RB68发布了新的文献求助30
10秒前
11秒前
12秒前
多元醇发布了新的文献求助10
12秒前
13秒前
13秒前
15秒前
JamesPei应助Pom采纳,获得10
15秒前
16秒前
活泼小霜发布了新的文献求助10
16秒前
完美世界应助知性的友易采纳,获得10
16秒前
无花果应助雅丽采纳,获得10
16秒前
16秒前
17秒前
17秒前
九千七发布了新的文献求助10
18秒前
18秒前
18秒前
田様应助多元醇采纳,获得10
18秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975250
求助须知:如何正确求助?哪些是违规求助? 3519625
关于积分的说明 11199055
捐赠科研通 3255962
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877358
科研通“疑难数据库(出版商)”最低求助积分说明 806298