Sulfonic Acid: Key Drug Design Elements With potent, broad-ranging Pharmacological Activities

钥匙(锁) 药物发现 药品 化学 医学 药理学 生物化学 计算机科学 计算机安全
作者
Lide Hu,Huinan Jia,Jiwei Zhang,Edeildo Ferreira da Silva‐Júnior,Chuanfeng Liu,Xinyong Liu,Peng Zhan
出处
期刊:Future Medicinal Chemistry [Newlands Press Ltd]
卷期号:15 (22): 2029-2032 被引量:4
标识
DOI:10.4155/fmc-2023-0257
摘要

Future Medicinal ChemistryVol. 15, No. 22 EditorialSulfonic acid: key drug design elements with potent, broad-ranging pharmacological activitiesLide Hu‡, Huinan Jia‡, Jiwei Zhang, Edeildo Ferreira da Silva-Júnior, Chuanfeng Liu, Xinyong Liu & Peng ZhanLide Hu‡Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR China, Huinan Jia‡Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR China, Jiwei ZhangDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR China, Edeildo Ferreira da Silva-JúniorBiological & Molecular Chemistry Research Group, Institute of Chemistry & Biotechnology, Federal University of Alagoas, Lourival Melo Mota Avenue, AC, Simoes Campus, Alagoas, Macei, 57072-970, Brazil, Chuanfeng Liu*Author for correspondence: E-mail Address: liuchuanfeng214@163.comDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR ChinaSuzhou Research Institute of Shandong University, Room 607, Building B of NUSP, NO. 388 Ruoshui Road, SIP, Suzhou, Jiangsu, 215123, PR China, Xinyong Liu**Author for correspondence: E-mail Address: xinyongl@sdu.edu.cnDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR China & Peng Zhan ***Author for correspondence: E-mail Address: zhanpeng1982@sdu.edu.cnhttps://orcid.org/0009-0003-4356-4594Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong, 250012, PR ChinaPublished Online:6 Nov 2023https://doi.org/10.4155/fmc-2023-0257AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: drug designmedicinal chemistrysulfonic acidReferences1. Guimond SE, Mycroft-West CJ, Gandhi NS et al. Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike-ACE2 interaction. ACS Cent. Sci. 8(5), 527–545 (2022).Crossref, Medline, CAS, Google Scholar2. Bojadzic D, Alcazar O, Chen J et al. Small-Molecule inhibitors of the coronavirus spike: ACE2 protein-protein iteraction as blockers of viral attachment and entry for SARS-CoV-2. ACS Infect. Dis. 7(6), 1519–1534 (2021).Crossref, Medline, CAS, Google Scholar3. Kuroki A, Tay DJW, Chua ACY et al. Amphiphilic sulfonated polycarbonates inactivate SARS-CoV-2 in seconds. Macromolecules 56(15), 6003–6009 (2023).Crossref, CAS, Google Scholar4. Liu Y, Zhang L, Yan H et al. Design of dimeric bile acid derivatives as potent and selective human NTCP inhibitors. J. Med. Chem. 64(9), 5973–6007 (2021).Crossref, Medline, CAS, Google Scholar5. Tebas P, Powderly WG. Nelfinavir mesylate. Expert Opin. Pharmacol. 1(7), 1429–1440 (2000).Crossref, Medline, CAS, Google Scholar6. Tan GT, Wickramasinghe A, Verma S et al. Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities. J. Med. Chem. 35(26), 4846–4853 (1992).Crossref, Medline, CAS, Google Scholar7. Mohan P, Wong MF, Verma S, Huang PP, Wickramasinghe A, Baba M. Structure-activity relationship studies with symmetric naphthalenesulfonic acid derivatives. Synthesis and influence of spacer and naphthalenesulfonic acid moiety on anti-HIV-1 activity. J. Med. Chem. 37(16), 2513–2519 (1994).Crossref, Medline, CAS, Google Scholar8. Sepúlveda-Crespo D, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. Nanoscale 10(19), 8998–9011 (2018).Crossref, Medline, CAS, Google Scholar9. Hong BT, Cheng YE, Cheng TJ, Fang JM. Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: synthesis and anti-influenza activity. Eur. J. Med. Chem. 163, 710–721 (2019).Crossref, Medline, CAS, Google Scholar10. Razinkov V, Gazumyan A, Nikitenko A, Ellestad G, Krishnamurthy G. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem. Biol. 8(7), 645–659 (2001).Crossref, Medline, CAS, Google Scholar11. He R, Wang J, Yu ZH et al. Structure-based design of active-site-directed, highly potent, selective, and orally bioavailable low-molecular-weight protein tyrosine phosphatase inhibitors. J. Med. Chem. 65(20), 13892–13909 (2022).Crossref, Medline, CAS, Google Scholar12. He R, Wang J, Yu ZH et al. Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J. Med. Chem. 59(19), 9094–9106 (2016).Crossref, Medline, CAS, Google Scholar13. Macedo T, Paiva-Martins F, Ferreres F et al. Anti-inflammatory effects of naringenin 8-sulphonate from parinari excelsa sabine stem bark and its semi-synthetic derivatives. Bioorg. Chem. 138, doi: 10.1016/j.bioorg.2023.106614 (2023).Crossref, Medline, Google Scholar14. Matesanz M, Mensa J. Ceftazidime-avibactam. Rev. Esp. Quimioter. 34(Suppl. 1), 38–40 (2021).Crossref, Medline, Google Scholar15. Heo YA. Imipenem/cilastatin/relebactam: a review in Gram-negative bacterial infections. Drugs 81(3), 377–388 (2021).Crossref, Medline, CAS, Google Scholar16. Büscher P, Cecchi G, Jamonneau V, Priotto G. Human african trypanosomiasis. Lancet 390(10110), 2397–2409 (2017).Crossref, Medline, Google Scholar17. Hawking F. Chemotherapy of onchocerciasis. Transactions of the Royal Society of Tropical Medicine. Hygiene 52(2), 109–111 (1958).CAS, Google Scholar18. Yahi N, Sabatier JM, Nickel P, Mabrouk K, Gonzalez-Scarano F, Fantini J. Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells. J. Biol. Chem. 269(39), 24349–24353 (1994).Crossref, Medline, CAS, Google Scholar19. Sahu D, Saroha A, Roy S, Das S, Srivastava PS, Das HR. Suramin ameliorates collagen induced arthritis. Int. Immunopharmacol. 12(1), 288–293 (2012).Crossref, Medline, CAS, Google Scholar20. Williams WL. The effects of suramin (germanin), azo dyes, and vasodilators on mice with transplanted lymphosarcomas. Cancer Res. 6, 344–353 (1946).Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 22 STAY CONNECTED Metrics Downloaded 25 times History Received 1 September 2023 Accepted 15 September 2023 Published online 6 November 2023 Published in print November 2023 Information© 2023 Newlands PressKeywordsdrug designmedicinal chemistrysulfonic acidAuthor contributionsThe writing of the first draft was initiated by C Liu, L Hu and H Jia. E Ferreira da Silva-Júnior, X Liu and P Zhan edited the manuscript. P Zhan reviewed and approved the final manuscript.Financial disclosureThe authors have received financial support from the National Natural Science Foundation of China (NSFC nos. 82173677, 82211530493), and the Science Foundation for Outstanding Young Scholars of Shandong Province (ZR2020JQ31). Natural Science Foundation of Jiangsu Province (SBK2023041680); China Postdoctoral Science Foundation (2022M711938). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
keanu发布了新的文献求助10
刚刚
AD钙钙钙发布了新的文献求助10
刚刚
愉快数据线完成签到 ,获得积分10
刚刚
苏蔚完成签到,获得积分10
刚刚
张弛华完成签到,获得积分10
1秒前
Jiang发布了新的文献求助10
1秒前
psy发布了新的文献求助10
1秒前
1秒前
三十三天完成签到 ,获得积分10
2秒前
笑点低的泥猴桃完成签到,获得积分10
2秒前
寻找完成签到,获得积分10
2秒前
2秒前
MaoTing完成签到,获得积分10
2秒前
小六子完成签到,获得积分10
2秒前
2秒前
小发发完成签到,获得积分10
2秒前
3秒前
大模型应助坦率的大侠采纳,获得10
3秒前
3秒前
强健的梦蕊完成签到,获得积分10
3秒前
weiww关注了科研通微信公众号
3秒前
4秒前
4秒前
4秒前
健康的海完成签到,获得积分10
4秒前
Shawn发布了新的文献求助10
4秒前
杨明智完成签到 ,获得积分10
4秒前
4秒前
冬瓜熊发布了新的文献求助10
4秒前
脑洞疼应助狂野的斑马采纳,获得10
4秒前
5秒前
荣哥儿发布了新的文献求助10
5秒前
5秒前
Lny应助呼呼采纳,获得10
5秒前
麦子应助呼呼采纳,获得10
6秒前
6秒前
Sea_U应助呼呼采纳,获得10
6秒前
6秒前
guan完成签到,获得积分10
6秒前
zhaiyi发布了新的文献求助10
6秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Handbook of pharmaceutical excipients, Ninth edition 5000
Aerospace Standards Index - 2026 ASIN2026 2000
Digital Twins of Advanced Materials Processing 2000
Social Cognition: Understanding People and Events 1200
Polymorphism and polytypism in crystals 1000
Signals, Systems, and Signal Processing 610
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 纳米技术 有机化学 物理 生物化学 化学工程 计算机科学 复合材料 内科学 催化作用 光电子学 物理化学 电极 冶金 遗传学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 6038095
求助须知:如何正确求助?哪些是违规求助? 7764679
关于积分的说明 16221689
捐赠科研通 5184251
什么是DOI,文献DOI怎么找? 2774457
邀请新用户注册赠送积分活动 1757359
关于科研通互助平台的介绍 1641651