Case report: Rare neurological symptoms of sulfasalazine‐induced hypersensitivity syndrome

International Journal of Rheumatic DiseasesVolume 27, Issue 3 e15108 LETTER TO THE EDITOR Case report: Rare neurological symptoms of sulfasalazine-induced hypersensitivity syndrome Yiqi Shen, Yiqi Shen orcid.org/0009-0008-5195-5129 Wenzhou Medical University, Wenzhou, ChinaSearch for more papers by this authorSijie Li, Sijie Li Wenzhou Medical University, Wenzhou, ChinaSearch for more papers by this authorMengting Qian, Mengting Qian Department of Rehabilitation, Ningbo Ninth Hospital, Ningbo, ChinaSearch for more papers by this authorXiaoru Xia, Corresponding Author Xiaoru Xia [email protected] orcid.org/0000-0002-5280-7100 Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Correspondence Xiaoru Xia, Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Email: [email protected]Search for more papers by this author Yiqi Shen, Yiqi Shen orcid.org/0009-0008-5195-5129 Wenzhou Medical University, Wenzhou, ChinaSearch for more papers by this authorSijie Li, Sijie Li Wenzhou Medical University, Wenzhou, ChinaSearch for more papers by this authorMengting Qian, Mengting Qian Department of Rehabilitation, Ningbo Ninth Hospital, Ningbo, ChinaSearch for more papers by this authorXiaoru Xia, Corresponding Author Xiaoru Xia [email protected] orcid.org/0000-0002-5280-7100 Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Correspondence Xiaoru Xia, Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Email: [email protected]Search for more papers by this author First published: 15 March 2024 https://doi.org/10.1111/1756-185X.15108 Yiqi Shen and Sijie Li contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Open Research DATA AVAILABILITY STATEMENT Data sharing is not applicable to this article as no new data were created or analyzed in this study. Supporting Information Filename Description apl15108-sup-0001-AppendixS1.docxWord 2007 document , 43 KB Appendix S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Hama N, Abe R, Gibson A, Phillips EJ. Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): clinical features and pathogenesis. J Allergy Clin Immunol Pract. 2022; 10(5): 1155-1168. 10.1016/j.jaip.2022.02.004 CASPubMedWeb of Science®Google Scholar 2Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol. 2007; 156(5): 1083-1084. 10.1111/j.1365-2133.2007.07807.x CASPubMedWeb of Science®Google Scholar 3Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998; 101(5): 1163-1174. 10.1172/JCI992 CASPubMedWeb of Science®Google Scholar 4Chidley C, Haruki H, Pedersen MG, Muller E, Johnsson K. A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis. Nat Chem Biol. 2011; 7(6): 375-383. 10.1038/nchembio.557 CASPubMedWeb of Science®Google Scholar 5Eichwald T, da Silva LD, Pires ACS, et al. Tetrahydrobiopterin: beyond its traditional role as a cofactor. Antioxidants. 2023; 12(5): 27. 10.3390/antiox12051037 Google Scholar 6Fanet H, Capuron L, Castanon N, Calon F, Vancassel S. Tetrahydrobioterin (BH4) pathway: from metabolism to neuropsychiatry. Curr Neuropharmacol. 2021; 19(5): 591-609. CASPubMedWeb of Science®Google Scholar 7McHugh PC. The tetrahydrobiopterin pathway: a novel target for the treatment of depression. Pharmacogenomics. 2011; 12(12): 1625-1627. 10.2217/pgs.11.138 CASPubMedGoogle Scholar 8Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol. 2015; 29(2): 97-115. 10.1177/0269881114563634 PubMedWeb of Science®Google Scholar 9Lutgen V, Resch J, Qualmann K, et al. Behavioral assessment of acute inhibition of system x(c) (−) in rats. Psychopharmacology (Berl). 2014; 231(24): 4637-4647. 10.1007/s00213-014-3612-4 CASPubMedGoogle Scholar Volume27, Issue3March 2024e15108 ReferencesRelatedInformation