Regeneration of NAD(P)H and its Analogues by Photocatalysis with Ionized Carbon Nitride

光催化 氮化碳 NAD+激酶 催化作用 化学 氮化物 再生(生物学) 碳纤维 光化学 材料科学 核化学 无机化学 化学工程 生物化学 有机化学 生物 图层(电子) 复合数 工程类 复合材料 细胞生物学
作者
Zaixiang Xu,Fengcang Zhou,Hanchi Chen,Jianguo Wang
出处
期刊:ACS Catalysis [American Chemical Society]
卷期号:14 (8): 5868-5878 被引量:7
标识
DOI:10.1021/acscatal.4c00841
摘要

The regeneration of NAD(P)H and its analogues is crucial for biocatalytic processes. However, despite the efficiency of enzymatic catalysis in regenerating NAD(P)H, the sustainability of enzymes is often compromised, particularly under extreme catalytic conditions. Moreover, artificial cofactors may present advantages in certain reactions due to their stability and versatility, yet the substrate specificity of enzymes poses significant challenges to their regeneration through the enzymatic method. Therefore, it is imperative to develop a highly stable regeneration method that can be adapted to both natural and artificial cofactors. In this work, employing potassium-ion-doped carbon nitride (ionCN-0.2) as a catalyst not only achieves high-efficiency photocatalytic regeneration of NAD(P)H, comparable to that of glucose dehydrogenase (GDH), but also a remarkable ability to regenerate nicotinamide analogues. This enhanced performance stems from the tunable negative ζ-potential, which effectively adsorbs the positively charged [Cp*Rh(bpy)H2O]2+ mediator, resulting in enhanced regeneration kinetics of the nicotinamide moiety. The catalyst demonstrates superior performance compared to the reported systems; the optimal regeneration rate reaches 0.55 mmol L–1 gcat–1 min–1 and approaches enzymatic regeneration efficiency. Expanding the reaction conditions to a wider temperature and pH range also confirms the effectiveness and sufficient stability of this photocatalytic system, offering a promising strategy for stable cofactor regeneration in biocatalytic processes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小白研发布了新的文献求助10
1秒前
1秒前
1秒前
2秒前
3秒前
3秒前
科研小白完成签到,获得积分10
3秒前
濮阳映萱发布了新的文献求助10
4秒前
6秒前
yu发布了新的文献求助10
6秒前
LIFE2020完成签到 ,获得积分10
6秒前
玛卡巴卡完成签到,获得积分10
7秒前
cxzz发布了新的文献求助10
8秒前
StonesKing发布了新的文献求助10
8秒前
哼哼唧唧发布了新的文献求助10
9秒前
9秒前
10秒前
安静的叫兽完成签到,获得积分10
11秒前
充电宝应助濮阳映萱采纳,获得30
11秒前
量子星尘发布了新的文献求助30
11秒前
baolong完成签到,获得积分10
14秒前
14秒前
淡定犀牛完成签到,获得积分20
14秒前
CodeCraft应助小叶不吃香菜采纳,获得10
14秒前
15秒前
傲慢葫芦完成签到,获得积分10
16秒前
yu完成签到,获得积分10
16秒前
17秒前
傲慢葫芦发布了新的文献求助10
18秒前
tsw完成签到,获得积分10
18秒前
思源应助tdtk采纳,获得10
19秒前
19秒前
19秒前
英俊的铭应助江桥采纳,获得10
21秒前
田田完成签到 ,获得积分10
23秒前
Yhcir完成签到,获得积分10
23秒前
45度人发布了新的文献求助10
25秒前
25秒前
上官若男应助淡定犀牛采纳,获得10
26秒前
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Immigrant Incorporation in East Asian Democracies 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3972387
求助须知:如何正确求助?哪些是违规求助? 3516862
关于积分的说明 11185001
捐赠科研通 3252334
什么是DOI,文献DOI怎么找? 1796376
邀请新用户注册赠送积分活动 876339
科研通“疑难数据库(出版商)”最低求助积分说明 805513