生物粘附
明胶
强力霉素
自愈水凝胶
伤口愈合
伤口敷料
烧伤
生物相容性
材料科学
抗菌活性
生物医学工程
医学
药物输送
外科
抗生素
化学
纳米技术
细菌
高分子化学
冶金
遗传学
复合材料
生物
生物化学
作者
Yan Hu,Bangrui Yu,Yuanbo Jia,Meng Li,Zhijie Li,Hao Líu,Hung-Chun Huang,Feng Xing,Jing Li,Wei Zhao
标识
DOI:10.1016/j.actbio.2023.04.021
摘要
Infection is a critical challenge in burn wound therapy. Wound dressings with antibacterial and multifunctional abilities associated with rapid burn wound healing are urgently needed. Here, we developed a bioadhesive and injectable ECM-mimicking hydrogel dressing with antibacterial capacity for burn injury therapy, which is crosslinked by dynamic boronate ester bonds between modified hyaluronate and gelatin (HG). The antibiotic doxycycline (Doxy) was encapsulated in HG networks for drug delivery around the wound sites. The HG/Doxy hydrogel dressing shows biocompatibility and antibacterial activity against Gram-positive and Gram-negative bacteria. Applying to a rat model of burn wound, the HG/Doxy hydrogel significantly speeds up wound closure by reducing the inflammatory reaction. Furthermore, the HG/Doxy hydrogel accelerates the regeneration of the skin structure by promoting collagen deposition, blood vessel regeneration, and hair follicle formation, eventually shortening the healing periods of burn wounds. These findings demonstrated the clinical potential of the HG/Doxy hydrogels as a promising burn wound dressing. STATEMENT OF SIGNIFICANCE: A bioadhesive and injectable hydrogel dressing has been developed for burn injury therapy. The ECM-mimicking hyaluronate-gelatin (HG) hydrogel with antibacterial ability is crosslinked by dynamic boronate ester bonds for delivering antibiotic doxycycline (Doxy). The HG/Doxy hydrogels exhibit bioadhesive, shape-adaptive, and water retention abilities in closing the irregular-shaped wound and providing a moist environment. The HG/Doxy hydrogels significantly shorten the healing periods of burn wounds in rat models within 10~14 days and promote the regeneration of skin structure, which have high potential for clinical applications.
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