A supramolecular assembly strategy for hydrophilic drug delivery towards synergistic cancer treatment

药物输送 纳米技术 材料科学 癌症 超分子化学 药品 抗癌药物 药理学 化学 医学 有机化学 内科学 晶体结构
作者
Haijing Qu,Han Chen,Wei Cheng,Yanjun Wang,Yangyang Xia,Linghao Zhang,Buyong Ma,Rong Hu,Xiangdong Xue
出处
期刊:Acta Biomaterialia [Elsevier]
卷期号:164: 407-421 被引量:12
标识
DOI:10.1016/j.actbio.2023.04.026
摘要

To improve the drug loading, tumor targeting, and delivery simplicity of hydrophilic drugs, we propose a supramolecular assembly strategy that potentially benefits a wide range of hydrophilic drug delivery. Firstly, we choose a hydrophilic drug (tirapazamine) as a model drug to directly co-assemble with chlorin e6 (Ce6) at different molar ratios, and systematically evaluate the resultant Ce6-tirapazamine nanoparticles (CT NPs) in aspects of size distribution, polydispersity, morphology, optical properties and molecular dynamics simulation. Based on the assembling facts between Ce6 and tirapazamine, we summarize a plausible rule of the supramolecular assembly for hydrophilic drugs. To validate our findings, more drugs with increasing hydrophilicity, such as temozolomide, gemcitabine hydrochloride and 5-azacytidine, successfully co-assemble with Ce6 into nanostructures by following similar assembling behaviors, demonstrating that our assembling rule may guide a wide range of hydrophilic drug delivery. Next, the combination of Ce6 and tirapazamine was chosen as the representative to investigate the anti-tumor activities of the supramolecular assemblies. CT NPs showed synergistic anti-tumor efficacy, increased tumor accumulation and significant tumor progression and metastasis inhibition in tumor-bearing mice. We anticipate that the supramolecular assembly mechanism will provide broad guidance for developing easy-to-make but functional nanomedicines. Although thousands of nanomedicines have been developed, only a few have been approved for clinical use. The manufacturing complexity significantly hinders the "bench-to-bed" translation of nanomedicines. Hence, we need to rethink how to conduct research on translational nanomedicines by avoiding more and more complex chemistry and complicated nanostructures. Here, we summarize a plausible rule according to multiple supramolecular assembly pairs and propose a supramolecular assembly strategy that can improve the drug loading, tumor targeting, and manufacturing simplicity of nanomedicine for hydrophilic drugs. The supramolecular assembly strategy would guide a broader range of drug delivery to provide a new paradigm for developing easy-to-make but multifunctional nanoformulations for synergistic cancer treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
邓力应助呆萌映寒采纳,获得20
1秒前
科研通AI2S应助自然的眼神采纳,获得10
1秒前
1秒前
和平使命发布了新的文献求助10
2秒前
高翔完成签到,获得积分10
3秒前
4秒前
4秒前
华仔应助kk采纳,获得10
4秒前
4秒前
萨尔莫斯完成签到,获得积分10
5秒前
bfhlf发布了新的文献求助10
6秒前
华仔应助鳗鱼凡波采纳,获得150
6秒前
兴奋的小笼包完成签到,获得积分20
7秒前
慧海拾穗完成签到 ,获得积分10
8秒前
兜兜揣满糖完成签到 ,获得积分10
8秒前
感性的初兰完成签到,获得积分10
9秒前
Clover完成签到,获得积分10
9秒前
今后应助阿欢采纳,获得30
10秒前
123完成签到,获得积分10
10秒前
11秒前
敬老院N号应助亮亮来咯采纳,获得30
13秒前
情怀应助平常的擎宇采纳,获得20
13秒前
KWang应助cookieMichael采纳,获得10
13秒前
mysoul123完成签到 ,获得积分10
13秒前
趣多多发布了新的文献求助30
13秒前
13秒前
美满雨莲完成签到,获得积分10
15秒前
16秒前
17秒前
你里其完成签到,获得积分10
18秒前
20秒前
李金玉完成签到,获得积分10
20秒前
22秒前
端庄含灵发布了新的文献求助10
23秒前
三七发布了新的文献求助10
25秒前
25秒前
大龄中二病完成签到,获得积分20
25秒前
抱住仙人球应助fenglinyi采纳,获得10
25秒前
topsun发布了新的文献求助10
30秒前
bfhlf发布了新的文献求助10
31秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3053902
求助须知:如何正确求助?哪些是违规求助? 2711045
关于积分的说明 7424610
捐赠科研通 2355580
什么是DOI,文献DOI怎么找? 1247273
科研通“疑难数据库(出版商)”最低求助积分说明 606339
版权声明 596012