脂质代谢
乳腺癌
癌症
肿瘤微环境
重编程
癌细胞
脂滴
癌症研究
生物
细胞信号
细胞生物学
细胞
信号转导
生物化学
遗传学
作者
Qian Xiao,Min Xia,Weijian Tang,Zhao Hu,Yajun Chen,Jing Zhong
出处
期刊:Cancer Letters
[Elsevier]
日期:2023-11-28
卷期号:582: 216512-216512
被引量:8
标识
DOI:10.1016/j.canlet.2023.216512
摘要
Lipids, as one of the three primary energy sources, provide energy for all cellular life activities. Lipids are also known to be involved in the formation of cell membranes and play an important role as signaling molecules in the intracellular and microenvironment. Tumor cells actively or passively remodel lipid metabolism, using the function of lipids in various important cellular life activities to evade therapeutic attack. Breast cancer has become the leading cause of cancer-related deaths in women, which is partly due to therapeutic resistance. It is necessary to fully elucidate the formation and mechanisms of chemoresistance to improve breast cancer patient survival rates. Altered lipid metabolism has been observed in breast cancer with therapeutic resistance, indicating that targeting lipid reprogramming is a promising anticancer strategy.
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