作者
Johan L.K. Van Hove,Marisa W. Friederich,Dana Strode,Roxanne A. Van Hove,Kristen Campbell,Rohit Sharma,Hardik Shah,Jane Estrella,Linda Gabel,Simon Horslen,Rohit Kohli,Mark A. Lovell,Alexander Miethke,Jean P. Molleston,René Romero,James E. Squires,Estella M. Alonso,Maria Oliva‐Hemker,Binita M. Kamath,Kathleen M. Loomes,Philip Rosenthal,Krupa R. Mysore,Laurel Cavallo,Pamela L. Valentino,John C. Magee,Shikha S. Sundaram,Ronald J. Sokol
摘要
Mitochondrial hepatopathies (MHs) are primary mitochondrial genetic disorders that can present as childhood liver disease. No recognized biomarkers discriminate MH from other childhood liver diseases. The protein biomarkers growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) differentiate mitochondrial myopathies from other myopathies. We evaluated these biomarkers to determine if they discriminate MH from other liver diseases in children.
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