苯并噻唑
衍生工具(金融)
线粒体DNA
线粒体
化学
G-四倍体
细胞生物学
癌症研究
生物
生物化学
DNA
基因
金融经济学
经济
作者
Ranran Sun,Hongxia Sun,YE Xiong-jun,Dawei Yang,Boyang Zhang,Yan Liu,Bai Renju,Fangchuan Zhong,Li Yao,Yalin Tang
标识
DOI:10.1016/j.snb.2024.135524
摘要
Emerging studies demonstrates that mitochondrial G-quadruplex (G4) may be a prospective diagnostic and therapeutic target for cancer. Fluorescent probes targeting mitochondrial G4 are crucial for in-depth research on G4 function and mechanism and developing new diagnostic techniques. Here, we report a benzothiazole derivative named ThT-E, which can be prepared with high yield through only one step of reaction. ThT-E exhibits superior detection sensitivity compared to existing probes, and also demonstrates reliable performance for in situ characterization of mitochondrial G4 in living cells. Interestingly, ThT-E has been used to differentiate tumor cells from normal cells by quantifying the formation of mitochondrial G4s, implicating that ThT-E may have wide applications in tumor diagnosis.
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