偷看
骨整合
生物相容性
化学
粘附
表面改性
植入
生物医学工程
矿化(土壤科学)
体外
表面粗糙度
金黄色葡萄球菌
材料科学
生物物理学
生物化学
复合材料
外科
细菌
医学
聚合物
生物
有机化学
物理化学
氮气
遗传学
作者
Rongxin Wan,Xiaojuan Wang,Li Lei,Guoying Hu,Huiqing Tang,Hanqing Gu
标识
DOI:10.1016/j.colsurfb.2022.112719
摘要
Polyetheretherketone (PEEK) has been widely applied for orthopedic and oral implants due to its excellent mechanical properties, biocompatibility, and radiolucency. However, its bioinert and the lack of anti-microbial activity limit its application. We modified the PEEK surface with Ta/Cu co-implantation using plasma immersion ion-implantation technology. After implantation of Ta/Cu ions, the morphology and roughness of the PEEK surface were not significantly changed at micron level. We estimated the cytocompatibility, anti-microbial ability, and osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs) of the modified surfaces in vitro. Compared to the untreated surfaces, the Ta ion-treated surface showed improved adhesion, proliferation, ALP activity, ECM mineralization, and osteogenic gene expression of BMSCs. Further, the Cu ion-treated surface showed reduced initial adhesion and proliferation of Escherichia coli and Staphylococcus aureus in vitro and proliferation of Staphylococcus aureus in the mouse subcutaneous implant-associated infection model. According to a rat bone repair model, all Ta ion-implanted groups demonstrated improved new bone formation. In summary, Ta/Cu ion co-impanation improved anti-microbial activity and promoted osseointegration of the PEEK surface.
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