Cardiorespiratory Fitness and Mortality Risk Across the Spectra of Age, Race, and Sex

医学 心肺适能 百分位 人口学 内科学 老年学 数学 统计 社会学
作者
Peter Kokkinos,Charles Faselis,Immanuel Babu Henry Samuel,Andreas Pittaras,Michael Doumas,Rayelynn Murphy,Michael S. Heimall,Xuemei Sui,Jiajia Zhang,Jonathan Myers
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:80 (6): 598-609 被引量:153
标识
DOI:10.1016/j.jacc.2022.05.031
摘要

Cardiorespiratory fitness (CRF) is inversely associated with all-cause mortality. However, the association of CRF and mortality risk for different races, women, and elderly individuals has not been fully assessed.The aim of this study was to evaluate the association of CRF and mortality risk across the spectra of age, race, and sex.A total of 750,302 U.S. veterans aged 30 to 95 years (mean age 61.3 ± 9.8 years) were studied, including septuagenarians (n = 110,637), octogenarians (n = 26,989), African Americans (n = 142,798), Hispanics (n = 35,197), Native Americans (n = 16,050), and women (n = 45,232). Age- and sex-specific CRF categories (quintiles and 98th percentile) were established objectively on the basis of peak METs achieved during a standardized exercise treadmill test. Multivariable Cox models were used to estimate HRs and 95% CIs for mortality across the CRF categories.During follow-up (median 10.2 years, 7,803,861 person-years of observation), 174,807 subjects died, averaging 22.4 events per 1,000 person-years. The adjusted association of CRF and mortality risk was inverse and graded across the age spectrum, sex, and race. The lowest mortality risk was observed at approximately 14.0 METs for men (HR: 0.24; 95% CI: 0.23-0.25) and women (HR: 0.23; 95% CI: 0.17-0.29), with no evidence of an increase in risk with extremely high CRF. The risk for least fit individuals (20th percentile) was 4-fold higher (HR: 4.09; 95% CI: 3.90-4.20) compared with extremely fit individuals.The association of CRF and mortality risk across the age spectrum (including septuagenarians and octogenarians), men, women, and all races was inverse, independent, and graded. No increased risk was observed with extreme fitness. Being unfit carried a greater risk than any of the cardiac risk factors examined.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
AKYDXS完成签到,获得积分10
3秒前
昏睡的蟠桃应助Llllll采纳,获得200
3秒前
科研通AI2S应助hao采纳,获得10
3秒前
4秒前
4秒前
香蕉觅云应助阿湫采纳,获得10
5秒前
星辰大海应助星辰采纳,获得10
5秒前
阿卡宁完成签到,获得积分10
5秒前
lzw完成签到 ,获得积分10
5秒前
沉静烧仙草完成签到,获得积分20
6秒前
烟花应助嘉嘉琦采纳,获得10
6秒前
隐形曼青应助科研通管家采纳,获得10
6秒前
Hello应助科研通管家采纳,获得10
7秒前
Ava应助科研通管家采纳,获得10
7秒前
上官若男应助科研通管家采纳,获得10
7秒前
7秒前
赘婿应助科研通管家采纳,获得10
7秒前
烟花应助科研通管家采纳,获得10
7秒前
FashionBoy应助科研通管家采纳,获得10
7秒前
英俊的铭应助科研通管家采纳,获得10
7秒前
在水一方应助科研通管家采纳,获得10
7秒前
accepted应助科研通管家采纳,获得10
7秒前
脑洞疼应助科研通管家采纳,获得10
7秒前
7秒前
cdh1994应助kcmat采纳,获得10
7秒前
我是老大应助科研通管家采纳,获得10
7秒前
乐乐应助科研通管家采纳,获得10
7秒前
FashionBoy应助科研通管家采纳,获得10
7秒前
7秒前
上官若男应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
7秒前
我是老大应助科研通管家采纳,获得30
7秒前
脑洞疼应助科研通管家采纳,获得20
8秒前
科目三应助科研通管家采纳,获得30
8秒前
8秒前
完美世界应助科研通管家采纳,获得10
8秒前
8秒前
8秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048