Cardiorespiratory Fitness and Mortality Risk Across the Spectra of Age, Race, and Sex

医学 心肺适能 百分位 人口学 内科学 老年学 数学 统计 社会学
作者
Peter Kokkinos,Charles Faselis,Immanuel Babu Henry Samuel,Andreas Pittaras,Michael Doumas,Rayelynn Murphy,Michael S. Heimall,Xuemei Sui,Jiajia Zhang,Jonathan Myers
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:80 (6): 598-609 被引量:153
标识
DOI:10.1016/j.jacc.2022.05.031
摘要

Cardiorespiratory fitness (CRF) is inversely associated with all-cause mortality. However, the association of CRF and mortality risk for different races, women, and elderly individuals has not been fully assessed.The aim of this study was to evaluate the association of CRF and mortality risk across the spectra of age, race, and sex.A total of 750,302 U.S. veterans aged 30 to 95 years (mean age 61.3 ± 9.8 years) were studied, including septuagenarians (n = 110,637), octogenarians (n = 26,989), African Americans (n = 142,798), Hispanics (n = 35,197), Native Americans (n = 16,050), and women (n = 45,232). Age- and sex-specific CRF categories (quintiles and 98th percentile) were established objectively on the basis of peak METs achieved during a standardized exercise treadmill test. Multivariable Cox models were used to estimate HRs and 95% CIs for mortality across the CRF categories.During follow-up (median 10.2 years, 7,803,861 person-years of observation), 174,807 subjects died, averaging 22.4 events per 1,000 person-years. The adjusted association of CRF and mortality risk was inverse and graded across the age spectrum, sex, and race. The lowest mortality risk was observed at approximately 14.0 METs for men (HR: 0.24; 95% CI: 0.23-0.25) and women (HR: 0.23; 95% CI: 0.17-0.29), with no evidence of an increase in risk with extremely high CRF. The risk for least fit individuals (20th percentile) was 4-fold higher (HR: 4.09; 95% CI: 3.90-4.20) compared with extremely fit individuals.The association of CRF and mortality risk across the age spectrum (including septuagenarians and octogenarians), men, women, and all races was inverse, independent, and graded. No increased risk was observed with extreme fitness. Being unfit carried a greater risk than any of the cardiac risk factors examined.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
111发布了新的文献求助10
1秒前
1秒前
2秒前
Jasper应助眠茶醒药采纳,获得10
2秒前
4秒前
5秒前
轻轻发布了新的文献求助10
5秒前
四叶曦完成签到 ,获得积分10
5秒前
千寻完成签到 ,获得积分10
6秒前
ASXC完成签到,获得积分20
8秒前
ecoli发布了新的文献求助10
10秒前
慕青应助徐徐采纳,获得10
12秒前
还单身的竺完成签到 ,获得积分10
12秒前
13秒前
搜集达人应助Led采纳,获得10
15秒前
徐5V完成签到,获得积分10
16秒前
孙尉钦完成签到,获得积分10
18秒前
要减肥发布了新的文献求助10
19秒前
调调发布了新的文献求助10
19秒前
nki发布了新的文献求助10
21秒前
23秒前
丸子完成签到,获得积分10
24秒前
打打应助正直摇伽采纳,获得10
24秒前
111完成签到,获得积分10
25秒前
whh完成签到,获得积分10
26秒前
Advance.Cheng发布了新的文献求助10
26秒前
友好聋五完成签到,获得积分10
27秒前
量子星尘发布了新的文献求助10
27秒前
卡卡西应助调调采纳,获得30
28秒前
小满完成签到,获得积分10
29秒前
黄憨憨发布了新的文献求助10
29秒前
爆米花应助松思采纳,获得30
30秒前
32秒前
要减肥完成签到 ,获得积分20
32秒前
yx_cheng应助andrele采纳,获得30
33秒前
34秒前
刘潮汕完成签到,获得积分20
35秒前
Lucas应助自由的凛采纳,获得10
36秒前
徐徐发布了新的文献求助10
36秒前
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976253
求助须知:如何正确求助?哪些是违规求助? 3520405
关于积分的说明 11203301
捐赠科研通 3257028
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877755
科研通“疑难数据库(出版商)”最低求助积分说明 806521