α病毒
核糖核酸
亚基因组mRNA
生物
RNA依赖性RNA聚合酶
蟾蜍科
病毒复制
RNA病毒
病毒学
抄写(语言学)
RNA编辑
非编码RNA
病毒
细胞生物学
遗传学
计算生物学
基因
哲学
语言学
作者
Kuo Zhang,Michelle Cheok Yien Law,Trinh Mai Nguyen,Yaw Bia Tan,Melissa Wirawan,Yee-Song Law,Lak Shin Jeong,Dahai Luo
出处
期刊:Cell Reports
[Elsevier]
日期:2022-07-01
卷期号:40 (4): 111133-111133
被引量:10
标识
DOI:10.1016/j.celrep.2022.111133
摘要
Many viruses encode RNA-modifying enzymes to edit the 5' end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms. Alphavirus nsP1 synthesizes the 5' end Cap-0 structure of viral RNAs. However, the molecular basis of the capping process remains unclear. We determine high-resolution cryoelectron microscopy (cryo-EM) structures of Chikungunya virus nsP1 in complex with m7GTP/SAH, covalently attached m7GMP, and Cap-0 viral RNA. These structures reveal details of viral-RNA-capping reactions and uncover a sequence-specific virus RNA-recognition pattern that, in turn, regulates viral-RNA-capping efficiency to ensure optimal genome replication and subgenomic RNA transcription. This sequence-specific enzyme-RNA pairing is conserved across all alphaviruses.
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