The landscape of programmed cell death-related lncRNAs in Alzheimer’s disease and Parkinson’s disease

神经退行性变 疾病 生物 自噬 程序性细胞死亡 基因 帕金森病 癌症研究 计算生物学 生物信息学 细胞凋亡 神经科学 遗传学 医学 病理
作者
Ning Zhao,J. Wang,Shan Huang,Jingyu Zhang,Jin Bao,Haisen Ni,Xinhang Gao,Chunlong Zhang
出处
期刊:Apoptosis [Springer Science+Business Media]
被引量:1
标识
DOI:10.1007/s10495-024-01984-z
摘要

This study delivers a thorough analysis of long non-coding RNAs (lncRNAs) in regulating programmed cell death (PCD), vital for neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD). We propose a new framework PCDLnc, and identified 20 significant lncRNAs, including HEIH, SNHG15, and SNHG5, associated with PCD gene sets, which were known for roles in proliferation and apoptosis in neurodegenerative diseases. By using GREAT software, we identified regulatory functions of top lncRNAs in different neurodegenerative diseases. Moreover, lncRNAs cis-regulated mRNAs linked to neurodegeneration, including JAK2, AKT1, EGFR, CDC42, SNCA, and ADIPOQ, highlighting their therapeutic potential in neurodegenerative diseases. A further exploration into the differential expression of mRNA identified by PCDLnc revealed a role in apoptosis, ferroptosis and autophagy. Additionally, protein-protein interaction (PPI) network analysis exposed abnormal interactions among key genes, despite their consistent expression levels between disease and normal samples. The randomforest model effectively distinguished between disease samples, indicating a high level of accuracy. Shared gene subsets in AD and PD might serve as potential biomarkers, along with disease-specific gene sets. Besides, we also found the strong relationship between AD and immune infiltration. This research highlights the role of lncRNAs and their associated genes in PCD in neurodegenerative diseases, offering potential therapeutic targets and diagnostic markers for future study and clinical application.
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