化学
肝细胞癌
多重耐药
配体（生物化学）
肝细胞
铂金
癌症研究
药理学
生物化学
组合化学
受体
体外
催化作用
医学
抗生素
作者
Xiaochao Huang,Jing Chen,Huifang Li,Wentian Zhong,Guiyang Jiang,Jinyuan Cai,Qingping Xiong,Chuang Wu,K. X. Su,Ri-Zhen Huang,Shiliu Xu,Zhikun Liu,Meng Wang,Heng‐Shan Wang
标识
DOI：10.1021/acs.jmedchem.4c00144
摘要
Promising targeted therapy options to overcome drug resistance and side effects caused by platinum(II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six novel multifunctional platinum(IV) complexes through linking platinum(II) agents and glycyrrhetinic acid (GA) were designed and synthesized. Among them, complex
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