Physically Crosslinked Polymeric Network for Controlled and Mucoadhesive Release of Miconazole for Topical Ocular Delivery

Background: Eudragit L100, filled with miconazole and gelatinous polymeric eye drops, is designed to sustain the drug release and increase ocular effect. Methods: The solvent diffusion technique was used to obtain the polymeric solution. The formulations developed were fully characterized and examined. Results: The optimized drug had a particle size of 71.15 2.3 nm, a zeta potential of approx. 2.57 to 0.76 mV, a polydispersity index of approx. 0.184 and a capture efficiency of 0.10% of 58.049. The prepared efforts showed a fungicidal effect on Candidiasis albicans cultures. Conclusion: The polymeric solution containing the drug-filled with miconazole (MZ) showed an abrupt release in the first hours, followed by the pattern of sustained drug release. A higher cumulative corneal permeability was observed from MZ-containing polymeric solution, which prolonged MZ release in goat eyes. Mucoadhesive liners containing miconazole-loaded Eudragit L100 polymeric solution provide a promising approach to the ocular administration of miconazole (a fungicide) for the treatment of ocular infections requiring long-term drug administration.