A transition-metal-free azide-alkyne cycloaddition/oxetane ring opening cascade reaction for the construction of hydroxymethyl decorated triazole-fused piperazin-2-ones and [1,4]diazepin-4-ones

A versatile synthesis of functionalized triazole-fused piperazin-2-one and [1,4] diazepin-4-one scaffolds via cascade azide-alkyne cycloaddition/oxetane ring opening reaction is reported. This approach features broad functional group compatibility, high atom economy...