肌萎缩侧索硬化
神经退行性变
神经科学
氧化应激
背景(考古学)
医学
耐受性
疾病
生物信息学
心理学
病理
生物
内科学
古生物学
替代医学
作者
Fabiola De Marchi,Sakthipriyan Venkatesan,Massimo Saraceno,Letizia Mazzini,Elena Grossini
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2024-05-01
卷期号:23 (5): 588-601
被引量:2
标识
DOI:10.2174/1871527322666230330083757
摘要
The management of neurodegenerative diseases can be frustrating for clinicians, given the limited progress of conventional medicine in this context.For this reason, a more comprehensive, integrative approach is urgently needed. Among various emerging focuses for intervention, the modulation of central nervous system energetics, oxidative stress, and inflammation is becoming more and more promising.In particular, electrons leakage involved in the mitochondrial energetics can generate reactive oxygen-free radical-related mitochondrial dysfunction that would contribute to the etiopathology of many disorders, such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis, stroke, and amyotrophic lateral sclerosis (ALS).In this context, using agents, like acetyl L-carnitine (ALCAR), provides mitochondrial support, reduces oxidative stress, and improves synaptic transmission.This narrative review aims to update the existing literature on ALCAR molecular profile, tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.
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