干扰素
性二态性
生物
先天免疫系统
免疫系统
Ⅰ型干扰素
基因型
肥胖
内分泌学
基因
内科学
免疫学
遗传学
医学
作者
Dylan Harney,Michelle Cielesh,George E. Roberts,Isabelle K. Vila,Barney Viengkhou,Markus Höfer,Nadine Laguette,Mark Larance
出处
期刊:Cell Reports
[Elsevier]
日期:2023-06-01
卷期号:42 (6): 112559-112559
标识
DOI:10.1016/j.celrep.2023.112559
摘要
Intermittent fasting (IF) is an established intervention to treat the growing obesity epidemic. However, the interaction between dietary interventions and sex remains a significant knowledge gap. In this study, we use unbiased proteome analysis to identify diet-sex interactions. We report sexual dimorphism in response to intermittent fasting within lipid and cholesterol metabolism and, unexpectedly, in type I interferon signaling, which was strongly induced in females. We verify that secretion of type I interferon is required for the IF response in females. Gonadectomy differentially alters the every-other-day fasting (EODF) response and demonstrates that sex hormone signaling can either suppress or enhance the interferon response to IF. IF fails to potentiate a stronger innate immune response when IF-treated animals were challenged with a viral mimetic. Lastly, the IF response changes with genotype and environment. These data reveal an interesting interaction between diet, sex, and the innate immune system.
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