蛋氨酸
转移
癌症研究
沙门氏菌
生物
癌症
细胞
遗传学
细菌
氨基酸
作者
Sujin Zhou,Yan Lin,Zhenggang Zhao,Yunhao Lai,Mengmeng Lü,Zishen Shao,Xinyu Mo,Yunping Mu,Zhipeng Liang,Xinxing Wang,Jingming Qu,Hua Shen,Fanghong Li,Allan Z. Zhao
标识
DOI:10.1016/j.xcrm.2023.101070
摘要
The strong dependency of almost all malignant tumors on methionine potentially offers a pathway for cancer treatment. We engineer an attenuated strain of Salmonella typhimurium to overexpress an L-methioninase with the aim of specifically depriving tumor tissues of methionine. The engineered microbes target solid tumors and induce a sharp regression in several very divergent animal models of human carcinomas, cause a significant decrease in tumor cell invasion, and essentially eliminate the growth and metastasis of these tumors. RNA sequencing analyses reveal that the engineered Salmonella reduce the expression of a series of genes promoting cell growth, cell migration, and invasion. These findings point to a potential treatment modality for many metastatic solid tumors, which warrants further tests in clinical trials.
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