A Model Combining Testosterone, Androstenedione and Free Testosterone Index Improved the Diagnostic Efficiency of Polycystic Ovary Syndrome

多囊卵巢 游离雄激素指数 医学 内科学 高雄激素血症 内分泌学 硫酸脱氢表雄酮 雄烯二酮 睾酮(贴片) 促黄体激素 促卵泡激素 餐后 性激素结合球蛋白 雄激素 激素 胰岛素 胰岛素抵抗
作者
Wanwan Yi,Mengyu Zhang,XueYu Yuan,Lishuai Shi,Yuan Xie,Ming Sun,Jin Liu,Haidong Cai,Zhongwei Lv
出处
期刊:Endocrine Practice [Elsevier BV]
卷期号:29 (8): 629-636 被引量:3
标识
DOI:10.1016/j.eprac.2023.05.007
摘要

Hyperandrogenism is frequently observed in patients with polycystic ovary (PCO). The purpose of this study was to develop an easy-to-use tool for predicting polycystic ovary syndrome (PCOS) and to evaluate and compare the value of androstenedione (Andro) and other hormone indicators in the diagnosis of patients with hyperandrogenic PCOS.This study included 139 women diagnosed with hyperandrogenic PCOS according to the Rotterdam criteria and 74 healthy control women from Shanghai Tenth People's Hospital. The serum hormone levels of the patients and controls were measured using a chemiluminescence immunoassay and incorporated for further analysis.Total testosterone (TT), Andro, dehydroepiandrosterone sulfate (DHEAS), and free androgen index (FAI) were significantly higher in the PCOS group than the control group. Further, Andro, follicle-stimulating hormone (FSH), luteinizing hormone (LH), TT, FAI, and LH/FSH in the hyperandrostenedione group were higher than the normal Andro group. The Youden index was the highest for Andro (0.65), with 81.82% sensitivity and 83.16% specificity. Correlation analysis showed that FSH, LH, TT, FAI, insulin sensitivity index, and LH/FSH were positively correlated with Andro, while fasting blood glucose and 2-hour postprandial blood glucose were negatively correlated with Andro.The model using Andro, TT, and FAI may help to identifying women with undiagnosed PCOS. Serum Andro is a meaningful biomarker for hyperandrogenism in PCOS patients and may further aid disease diagnosis.
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