医学
哮喘
杜皮鲁玛
内科学
前瞻性队列研究
队列
作者
Andrea Portacci,Ilaria Iorillo,Vitaliano Nicola Quaranta,Leonardo Maselli,Ernesto Lulaj,Enrico Buonamico,Silvano Dragonieri,Giovanna Elisiana Carpagnano
标识
DOI:10.1016/j.rmed.2023.107348
摘要
Dupilumab, a fully human anti-interleukin-4/interleukin-13 monoclonal antibody, has shown efficacy in many aspects of Type-2 severe asthma management. Currently, we lack real-life studies addressing the achievment of clinical remission in patients treated with this biologic.We performed a prospective study enrolling 18 patients with severe asthma treated with Dupilumab. We assessed main clinical, functional and biological severe asthma features at baseline (T0) and after a 1-year course of treatment (T12). Clinical remission was defined at T12 in patients without asthma exacerbations, no oral corticosteroid (OCS) use, ACT ≥ 20 and FEV1 improvement ≥ 100 ml from baseline.Among total population, 38.9% of patients achieved clinical remission at T12. Anti IL-4/IL-13 treatment significantly reduced asthma exacerbations and OCS use in the overall cohort, with a more pronounced ACT improvement in the remission group. Patients achieving clinical remission went through a step down of the inhalation therapy, suspending long-acting anti-muscarinics administration at T12.Treatment with anti-IL4/IL13 can induce clinical remission in patients with T2 severe asthma.
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