Of tenants and nomads: The faces of memory T cells

Memory T cells comprise circulating and tissue-resident subsets. In this issue of Immunity, Evrard et al. generate an imputed high-dimensional, single-cell protein expression atlas of memory CD8+ T cells, providing insights into stable differentiation markers and organ-specific expression patterns. Memory T cells comprise circulating and tissue-resident subsets. In this issue of Immunity, Evrard et al. generate an imputed high-dimensional, single-cell protein expression atlas of memory CD8+ T cells, providing insights into stable differentiation markers and organ-specific expression patterns. Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancerZagorulya et al.ImmunityFebruary 2, 2023In BriefHow tissue-specific mechanisms shape anti-tumor immunity remains poorly understood. Zagorulya et al. reveal that lung lymph node (LN)-specific abundance of interferon-gamma induces suppressive Th1-like effector regulatory T (Treg) cells. These effector Treg cells interact with type 1 conventional dendritic cells and restrain priming of cytotoxic T cell responses against lung cancer. Full-Text PDF CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunityMoreno Ayala et al.ImmunityJune 30, 2023In BriefRegulatory T (Treg) cell accumulation in tumors suppresses antitumor immunity, but the mechanisms are incompletely understood. Here, Moreno Ayala et al. show that CXCR3 expression on Treg cells puts them in close proximity to CXCL9-producing dendritic cells in tumors, where they suppress tumor antigen presentation and impede the antitumor CD8+ T cell response. Full-Text PDF