Associations among bisphenol A, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: A case-control study

优势比 医学 置信区间 四分位数 逻辑回归 双酚A 体质指数 病例对照研究 产科 内科学 化学 环氧树脂 有机化学
作者
Haiyan Zhu,Qingli Cheng,Jufen Liu,Lei Jin,Jufen Liu,Aiguo Ren,Linlin Wang
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:900: 165586-165586 被引量:3
标识
DOI:10.1016/j.scitotenv.2023.165586
摘要

Bisphenol A (BPA) and its analogs such as bisphenol Z (BPZ) are widely used in the production of consumer products, but few studies have investigated the associations among BPA, its analogs, and chlorinated derivatives (collectively, BPs) and risk for NTDs. This study investigated the associations between concentrations of BPs in the placenta and risk for NTDs. This was a case-control study including 122 NTDs and 164 controls. BPs in the placenta were determined using liquid chromatography–tandem mass spectrometry. The associations between BPs and NTD risk were evaluated using conventional logistic regression and weighted quantile sum regression (WQS) models. In the logistic regression, exposure to higher levels of BPA and BPZ was associated with increased NTD risk (odds ratio [OR] = 3.17, 95 % confidence interval [CI], 1.22–8.22; OR = 3.11, 95 % CI, 1.20–8.09, respectively). Meanwhile, a significant dose–response relationship was found between BPA and BPZ concentrations and NTD risk. In the WQS model, a quartile increase in WQS index resulted in 4.34 (95 % CI: 1.69, 11.20) higher odds for NTDs, and BPA and BPZ accounted for most of the weight index in the joint effects of BPs. In conclusion, high levels of BPs in the placenta are associated with increased risk for NTDs, of which BPA and BPZ are important risk factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
瘦瘦天奇完成签到 ,获得积分10
刚刚
3秒前
CodeCraft应助阳光沛柔采纳,获得10
3秒前
4秒前
5秒前
轩辕寄风完成签到,获得积分0
7秒前
冉冉发布了新的文献求助10
9秒前
执着又蓝发布了新的文献求助20
9秒前
Rondab应助rrr采纳,获得10
9秒前
sjx1116完成签到 ,获得积分10
10秒前
Akim应助杜兰特工队采纳,获得10
13秒前
13秒前
14秒前
冉冉完成签到,获得积分10
16秒前
MTRQ给MTRQ的求助进行了留言
17秒前
面壁思过完成签到,获得积分10
18秒前
18秒前
Lucas应助科研通管家采纳,获得10
19秒前
猪猪hero应助科研通管家采纳,获得10
19秒前
猪猪hero应助科研通管家采纳,获得10
19秒前
科研通AI5应助科研通管家采纳,获得10
19秒前
Liufgui应助科研通管家采纳,获得10
19秒前
Bio应助科研通管家采纳,获得30
19秒前
MchemG应助科研通管家采纳,获得10
19秒前
20秒前
20秒前
传奇3应助科研通管家采纳,获得10
20秒前
20秒前
天天快乐应助roy采纳,获得10
22秒前
22秒前
rrr完成签到,获得积分10
24秒前
water完成签到,获得积分10
25秒前
Sea_U发布了新的文献求助10
27秒前
执着又蓝完成签到,获得积分20
28秒前
28秒前
量子星尘发布了新的文献求助10
29秒前
32秒前
35秒前
Sea_U完成签到,获得积分0
35秒前
坤坤完成签到,获得积分10
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988997
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253520
捐赠科研通 3269928
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068