囊性纤维化
医学
囊性纤维化跨膜传导调节器
不育
生殖健康
表型
男性不育
疾病
精索静脉曲张
病理生理学
睾酮(贴片)
生物信息学
生理学
内科学
怀孕
遗传学
人口
基因
环境卫生
生物
作者
Katherine Campbell,Mohamadhusni Zarli,Kyle Schuppe,Ryan Wong,Farah Rahman,Ranjith Ramasamy
出处
期刊:Urology
[Elsevier]
日期:2023-06-01
标识
DOI:10.1016/j.urology.2023.06.017
摘要
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Due to the distribution of the CFTR protein, CF presents with a heterogeneous phenotype. Men with CF may present with infertility due to congenital abnormalities of the vas deferens. In addition, they may experience testosterone deficiency. Today, they can father biological children with assisted reproductive technologies. We reviewed the current literature on the pathophysiology of these conditions, describe interventions that allow men with CF to conceive biological children, and provide recommendations for management of CF patients with reproductive health concerns.
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