Serendipitous crossed aldol reaction in the second coordination sphere of a Ru(II) polypyridyl complex in silica bed: prospect for delivering anticancer agents for photoactivated chemotherapy

This work provides a simple new strategy to design Ru( ii ) polypyridyl-based photoactivated chemotherapeutic agents via the attachment of ‘uncageable’ anticancer agents based on a serendipitous crossed aldol reaction in the ligand periphery.