曲妥珠单抗
转移性乳腺癌
乳腺癌
肿瘤科
医学
内分泌系统
内科学
癌症
激素
作者
Aditya Bardia,Xichun Hu,Rebecca Dent,Kan Yonemori,Carlos H. Barrios,Joyce O’Shaughnessy,Hans Wildiers,Jean‐Yves Pierga,Qingyuan Zhang,Cristina Saura,Laura Biganzoli,Joohyuk Sohn,Seock‐Ah Im,Christelle Lévy,William Jacot,Natasha Begbie,Jun Ke,Gargi Patel,Giuseppe Curigliano
标识
DOI：10.1056/nejmoa2407086
摘要
Among patients with hormone receptor-positive, HER2-low or HER2-ultralow metastatic breast cancer who had received one or more lines of endocrine-based therapy, treatment with trastuzumab deruxtecan resulted in longer progression-free survival than chemotherapy. No new safety signals were identified. (Funded by AstraZeneca and Daiichi Sankyo; DESTINY-Breast06 ClinicalTrials.gov number, NCT04494425.).
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(2025-6-4)
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