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Design, synthesis and application of polarity- and pH-sensitive dual-responsive small molecule fluorescent probe for early cancer diagnosis

荧光 极性(国际关系) 化学 对偶(语法数字) 分子 组合化学 癌症 生物物理学 纳米技术 光化学 生物化学 材料科学 有机化学 生物 物理 遗传学 光学 文学类 艺术 细胞
作者
Lumen Chao,Zuo‐Feng Zhang,Lu Ga,Jun Ai
出处
期刊:Microchemical Journal [Elsevier BV]
卷期号:205: 111250-111250 被引量:5
标识
DOI:10.1016/j.microc.2024.111250
摘要

CCT probes sensitive to low pH and low polarity were used to distinguish normal cells from cancer cells. • Designed and synthesised a fluorescent probe, CCT. • CCT is responsive to both pH and polarity based on the mechanisms of intramolecular charge transfer (ICT) and photoelectron transfer (PET). • The probe consists of a naphthylimide fluorophore, a coumarin unit and a morpholine. • CCT corresponds to the low pH and low polarity microenvironment of cancer cells, which is favourable for bioimaging. Cancer is one of the deadliest and most complex diseases globally. It is well known that cancer cells exhibit a unique intracellular microenvironment characterized by low pH and low polarity compared to normal cells. Thus, dual-responsive fluorescent probe are more suitable for such complex and variable physiological environments than single-response probe. In this study, we designed and synthesized a dual-responsive fluorescent probe, CCT, which responds to both pH and polarity based on intramolecular charge transfer (ICT) and photoelectron transfer (PET) mechanisms.We synthesized probe CCT by combining naphthylimide, a coumarin unit, and morpholine through a six-step process. The PET mechanism between morpholine and naphthylimide renders probe CCT pH-sensitive. Additionally, the direct linkage of the polarity-sensitive units, coumarin and naphthylimide, creates a larger polarity-sensitive system. When both low pH and low polarity conditions are present, the fluorescence intensity of probe CCT is significantly higher than under separate conditions. This increased fluorescence intensity matches the low pH and low polarity microenvironment of cancer cells, facilitating bioimaging.Fluorescence imaging results demonstrate that probe CCT effectively distinguishes between cancer and normal cells, suggesting its potential as a powerful tool for early cancer diagnosis.
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