甘草
PI3K/AKT/mTOR通路
查尔酮
作用机理
信号转导
蛋白激酶B
药理学
药物发现
生物
化学
细胞生物学
生物信息学
医学
生物化学
替代医学
病理
立体化学
体外
作者
Sibhghatulla Shaikh,Eun Ju Lee,Khurshid Ahmad,Inho Choi
标识
DOI:10.3389/fmolb.2024.1440132
摘要
Licochalcone B (LicB), a chalcone derived from Glycyrrhiza uralensis and Glycyrrhiza glabra, has received considerable attention due to its diverse pharmacological properties. Accumulated data indicates that LicB has pharmacological effects that include anti-cancer, hepatoprotective, anti-inflammatory, and neuroprotective properties. The action mechanism of LicB has been linked to several molecular targets, such as phosphoinositide 3-kinase/Akt/mammalian target of rapamycin, p53, nuclear factor-κB, and p38, and the involvements of caspases, apoptosis, mitogen-activated protein kinase-associated inflammatory pathways, and anti-inflammatory nuclear factor erythroid 2–related factor 2 signaling pathways highlight the multifaceted therapeutic potential of LicB. This review systematically updates recent findings regarding the pharmacological effects of LicB, and the mechanistic pathways involved, and highlights the potential use of LicB as a promising lead compound for drug discovery.
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